Bicalutamide Anticancer Activity Enhancement by Formulation of Soluble Inclusion Complexes with Cyclodextrins

Bicalutamide Anticancer Activity Enhancement by Formulation of Soluble Inclusion Complexes with Cyclodextrins

Bicalutamide (BCL) is a nonsteroidal antiandrogen drug that represents an alternative to castration in the treatment of prostate cancer, due to its relatively long half-life and tolerable side effects. However, it possesses a very low water solubility that can affect its oral bioavailability. In thi...

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Bibliographic Details
Main Authors: Federica De Gaetano, Maria Chiara Cristiano, Donatella Paolino, Consuelo Celesti, Daniela Iannazzo, Venerando Pistarà, Nunzio Iraci, Cinzia Anna Ventura
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biomolecules
Subjects:
bicalutamide
cyclodextrins
molecular modeling
in vitro biological studies
DU-145 and PC3 cell lines
Online Access:https://www.mdpi.com/2218-273X/12/11/1716

Internet

https://www.mdpi.com/2218-273X/12/11/1716

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