Synthesis, characterization, and in vitro-in ovo toxicological screening of silibinin fatty acids conjugates as prodrugs with potential biomedical applications

Synthesis, characterization, and in vitro-in ovo toxicological screening of silibinin fatty acids conjugates as prodrugs with potential biomedical applications

Silibinin (SIL), the most active phytocompound from Silybum marianum (L.), exerts many biological effects but has low stability and bioavailability. To overcome these drawbacks, the current research proposed the synthesis of silibilin oleate (SIL-O) and silibilin linoleate (SIL-L) derivatives as pr...

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Bibliographic Details
Main Authors: Cristina Dehelean, Ersilia Alexa, Iasmina Marcovici, Andrada Iftode, Geza Lazar, Andrea Simion, Vasile Chis, Adrian Pirnau, Simona Cinta Pinzaru, Estera Boeriu
Format: Article
Language:English
Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2024-06-01
Series:Biomolecules & Biomedicine
Subjects:
Silibinin
oleic acid
linoleic acid
derivatization
physico-chemical characterization
cytotoxicity
Online Access:https://www.bjbms.org/ojs/index.php/bjbms/article/view/10600

Internet

https://www.bjbms.org/ojs/index.php/bjbms/article/view/10600

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