Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers

Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers

Abstract Parkinson’s disease is mainly caused by aggregation of α-synuclein (α-syn) in the brain. Exchange of α-syn between the brain and peripheral tissues could have important pathophysiological and therapeutic implications, but the trafficking mechanism of α-syn across the blood brain-barrier (BB...

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Bibliographic Details
Main Authors: Parvez Alam, Mikkel R. Holst, Line Lauritsen, Janni Nielsen, Simone S. E. Nielsen, Poul Henning Jensen, Jonathan R. Brewer, Daniel E. Otzen, Morten S. Nielsen
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Fluids and Barriers of the CNS
Subjects:
α-synuclein
Parkinson’s disease
Rab7
Retromer
Polarization trap
Transcytosis
Online Access:https://doi.org/10.1186/s12987-022-00334-y

Internet

https://doi.org/10.1186/s12987-022-00334-y

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