Evaluation of COVID-19 Patients According to the Survival Time
Background: Coronavirus disease 2019 (COVID-19) was first detected as a form of atypical pneumonia. COVID-19 is a highly contagious virus, and some patients may experience acute respiratory distress syndrome (ARDS) and acute respiratory failure leading to death. We aim to evaluate the clinical, imag...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Interna Publishing
2022-04-01
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| Series: | Acta Medica Indonesiana |
| Subjects: | |
| Online Access: | https://actamedindones.org/index.php/ijim/article/view/2021 |
| _version_ | 1828780271551381504 |
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| author | Adem Atici Ramazan Asoglu Hasan Ali Barman Mustafa Adem Tatlisu Gönul Aciksari Yusuf Yilmaz Fatma Betul Ozcan Mustafa Caliskan |
| author_facet | Adem Atici Ramazan Asoglu Hasan Ali Barman Mustafa Adem Tatlisu Gönul Aciksari Yusuf Yilmaz Fatma Betul Ozcan Mustafa Caliskan |
| author_sort | Adem Atici |
| collection | DOAJ |
| description | Background: Coronavirus disease 2019 (COVID-19) was first detected as a form of atypical pneumonia. COVID-19 is a highly contagious virus, and some patients may experience acute respiratory distress syndrome (ARDS) and acute respiratory failure leading to death. We aim to evaluate the clinical, imaging, and laboratory parameters according to survival time to predict mortality in fatal COVID-19 patients. Methods: Fatal 350 and survived 150 COVID-19 patients were included in the study. Fatal patients were divided into three groups according to the median value of the survival days. Demographic characteristics and in-hospital complications were obtained from medical databases. Results: Of the non-survived patients, 30% (104) died within three days, 32% (110) died within 4-10 days, and 39% (136) died within over ten days. Pneumonia on computational tomography (CT), symptom duration before hospital admission (SDBHA), intensive care unit (ICU), hypertension (HT), C-reactive protein (CRP), D-dimer, multi-organ dysfunction syndrome (MODS), cardiac and acute kidney injury, left ventricular ejection fraction (LVEF), right ventricular fractional area change (RV-FAC), and Tocilizumab/Steroid therapy were independent predictors of mortality within three days compared to between 4-10 days and over ten days mortality. A combined diagnosis model was evaluated for the age, CT score, SDBHA, hs-TnI, and D-dimer. The combined model had a higher area under the ROC curve (0.913). Conclusion: This study showed that age, pneumonia on CT, SDBHA, ICU, HT, CRP, d-dimer, cardiac injury, MODS, acute kidney injury, LVEF, and RV-FAC were independently associated with short-term mortality in non-surviving COVID-19 patients in the Turkish population. Moreover, Tocilizumab/Steroid therapy was a protective and independent predictor of mortality within three days. |
| first_indexed | 2024-12-11T17:14:42Z |
| format | Article |
| id | doaj.art-82b60b3489fd430181a65bb9aa5e64d8 |
| institution | Directory Open Access Journal |
| issn | 0125-9326 2338-2732 |
| language | English |
| last_indexed | 2024-12-11T17:14:42Z |
| publishDate | 2022-04-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj.art-82b60b3489fd430181a65bb9aa5e64d82022-12-22T00:57:23ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322022-04-01542504Evaluation of COVID-19 Patients According to the Survival TimeAdem Atici0Ramazan Asoglu1Hasan Ali Barman2Mustafa Adem Tatlisu3Gönul Aciksari4Yusuf Yilmaz5Fatma Betul Ozcan6Mustafa Caliskan7Cardiology Department, Istanbul Medeniyet UniversityFaculty of Medicine, Goztepe Training and Research Hospital, Dr. Erkin street, 34722, Istanbul, Turkey.Cardiology Department, Adiyaman Training and Research Hospital, Yunus Emre Mahallesi, 1164 Sokak No:13, Merkez/Adıyaman, Turkey.Cardiology Department, Faculty of Medicine, Istanbul University – Cerrahpasa, Institute of Cardiology, Istanbul,Turkey.Cardiology Department, Istanbul Medeniyet UniversityFaculty of Medicine, Goztepe Training and Research Hospital, Dr. Erkin street, 34722, Istanbul, Turkey.Cardiology Department, Istanbul Medeniyet UniversityFaculty of Medicine, Goztepe Training and Research Hospital, Dr. Erkin street, 34722, Istanbul, Turkey.Cardiology Department, Istanbul Medeniyet UniversityFaculty of Medicine, Goztepe Training and Research Hospital, Dr. Erkin street, 34722, Istanbul, Turkey.Cardiology Department, Istanbul Medeniyet UniversityFaculty of Medicine, Goztepe Training and Research Hospital, Dr. Erkin street, 34722, Istanbul, Turkey.Cardiology Department, Istanbul Medeniyet UniversityFaculty of Medicine, Goztepe Training and Research Hospital, Dr. Erkin street, 34722, Istanbul, Turkey.Background: Coronavirus disease 2019 (COVID-19) was first detected as a form of atypical pneumonia. COVID-19 is a highly contagious virus, and some patients may experience acute respiratory distress syndrome (ARDS) and acute respiratory failure leading to death. We aim to evaluate the clinical, imaging, and laboratory parameters according to survival time to predict mortality in fatal COVID-19 patients. Methods: Fatal 350 and survived 150 COVID-19 patients were included in the study. Fatal patients were divided into three groups according to the median value of the survival days. Demographic characteristics and in-hospital complications were obtained from medical databases. Results: Of the non-survived patients, 30% (104) died within three days, 32% (110) died within 4-10 days, and 39% (136) died within over ten days. Pneumonia on computational tomography (CT), symptom duration before hospital admission (SDBHA), intensive care unit (ICU), hypertension (HT), C-reactive protein (CRP), D-dimer, multi-organ dysfunction syndrome (MODS), cardiac and acute kidney injury, left ventricular ejection fraction (LVEF), right ventricular fractional area change (RV-FAC), and Tocilizumab/Steroid therapy were independent predictors of mortality within three days compared to between 4-10 days and over ten days mortality. A combined diagnosis model was evaluated for the age, CT score, SDBHA, hs-TnI, and D-dimer. The combined model had a higher area under the ROC curve (0.913). Conclusion: This study showed that age, pneumonia on CT, SDBHA, ICU, HT, CRP, d-dimer, cardiac injury, MODS, acute kidney injury, LVEF, and RV-FAC were independently associated with short-term mortality in non-surviving COVID-19 patients in the Turkish population. Moreover, Tocilizumab/Steroid therapy was a protective and independent predictor of mortality within three days.https://actamedindones.org/index.php/ijim/article/view/2021covid-19mortalityacute respiratory distress syndromeechocardiography |
| spellingShingle | Adem Atici Ramazan Asoglu Hasan Ali Barman Mustafa Adem Tatlisu Gönul Aciksari Yusuf Yilmaz Fatma Betul Ozcan Mustafa Caliskan Evaluation of COVID-19 Patients According to the Survival Time Acta Medica Indonesiana covid-19 mortality acute respiratory distress syndrome echocardiography |
| title | Evaluation of COVID-19 Patients According to the Survival Time |
| title_full | Evaluation of COVID-19 Patients According to the Survival Time |
| title_fullStr | Evaluation of COVID-19 Patients According to the Survival Time |
| title_full_unstemmed | Evaluation of COVID-19 Patients According to the Survival Time |
| title_short | Evaluation of COVID-19 Patients According to the Survival Time |
| title_sort | evaluation of covid 19 patients according to the survival time |
| topic | covid-19 mortality acute respiratory distress syndrome echocardiography |
| url | https://actamedindones.org/index.php/ijim/article/view/2021 |
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