Trypanosoma cruzi Infection Induces Cellular Stress Response and Senescence-Like Phenotype in Murine Fibroblasts

Trypanosoma cruzi Infection Induces Cellular Stress Response and Senescence-Like Phenotype in Murine Fibroblasts

Trypanosoma cruzi infects and replicates within a wide variety of immune and non-immune cells. Here, we investigated early cellular responses induced in NIH-3T3 fibroblasts upon infection with trypomastigote forms of T. cruzi. We show that fibroblasts were susceptible to T. cruzi infection and start...

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Bibliographic Details
Main Authors: Kamila Guimarães-Pinto, Danielle Oliveira Nascimento, Antonia Corrêa-Ferreira, Alexandre Morrot, Celio G. Freire-de-Lima, Marcela F. Lopes, George A. DosReis, Alessandra A. Filardy
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
Chagas disease
Trypanosoma cruzi
senescent-like
senescence-associated β-galactosidase
senescence-associated secretory phenotype
reactive oxygen species
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01569/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01569/full

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