Use of X-ray Microscopy for Confirmation of Crystallinity Detection in Amorphous Formulations by Electrospray Laser Desorption Ionization Mass Spectrometry Imaging

Use of X-ray Microscopy for Confirmation of Crystallinity Detection in Amorphous Formulations by Electrospray Laser Desorption Ionization Mass Spectrometry Imaging

The use of mass spectrometry imaging for crystallinity detection offers improved matrix selectivity and sensitivity over the techniques, such as X-ray microscopy and Raman spectrometry, that are traditionally used with this work. Crystallinity is observed in electrospray laser desorption ionization...

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Bibliographic Details
Main Authors: Kelsey K. Ramp, Noah R. Dierckman, Margaret A. Sperry, Matthew E. Reuter, Yongan Tang, Gregory K. Webster, Patrick A. McVey
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Crystals
Subjects:
electrospray laser desorption ionization
ELDI
mass spectrometry imaging
MSI
X-ray microscopy
micro-CT
Online Access:https://www.mdpi.com/2073-4352/13/10/1418

Internet

https://www.mdpi.com/2073-4352/13/10/1418

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