Ion channel gene GJB2 influences the intercellular communication by Up-regulating the SPP1 signaling pathway identified by the single-cell RNA sequencing in lung adenocarcinoma

Ion channel gene GJB2 influences the intercellular communication by Up-regulating the SPP1 signaling pathway identified by the single-cell RNA sequencing in lung adenocarcinoma

ObjectiveFirstly, observe the prognostic significance and the biological functional effects of gap junction protein beta 2 (GJB2 or Cx26) in lung adenocarcinoma (LUAD). Subsequently, explore the role played by GJB2 in intercellular communication by single-cell RNA sequencing.MethodWe made a differen...

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Bibliographic Details
Main Authors: Zuo Liu, Zengtuan Xiao, Xiaofei Wang, Lianmin Zhang, Zhenfa Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Oncology
Subjects:
GJB2
SPP1
lung adenocarcinoma
immune infiltration
intercellular communication
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1146976/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1146976/full

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