Plasma Prekallikrein: Its Role in Hereditary Angioedema and Health and Disease

Plasma Prekallikrein: Its Role in Hereditary Angioedema and Health and Disease

Plasma prekallikrein (PK) has a critical role in acute attacks of hereditary angioedema (HAE). Unlike C1 inhibitor, its levels fall during HAE attacks with resultant cleaved high-molecular-weight kininogen. Cleavage of high-molecular-weight kininogen liberates bradykinin, the major biologic peptide...

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Bibliographic Details
Main Author: Alvin H. Schmaier
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Medicine
Subjects:
prekallikrein
plasma kallikrein
hereditary angioedema
high-molecular-weight kininogen
factor XII
fletcher trait
Online Access:http://journal.frontiersin.org/article/10.3389/fmed.2018.00003/full

Internet

http://journal.frontiersin.org/article/10.3389/fmed.2018.00003/full

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