Autophagy impairment in patients with obstructive sleep apnea modulates intermittent hypoxia-induced oxidative stress and cell apoptosis via hypermethylation of the ATG5 gene promoter region

Autophagy impairment in patients with obstructive sleep apnea modulates intermittent hypoxia-induced oxidative stress and cell apoptosis via hypermethylation of the ATG5 gene promoter region

Abstract Background Autophagy is a catabolic process that recycles damaged organelles and acts as a pro-survival mechanism, but little is known about autophagy dysfunction and epigenetic regulation in patients with obstructive sleep apnea (OSA). Methods Protein/gene expressions and DNA methylation l...

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Bibliographic Details
Main Authors: Yung-Che Chen, I-Chun Lin, Mao-Chang Su, Po-Yuan Hsu, Chang-Chun Hsiao, Te-Yao Hsu, Chia-Wei Liou, Yu-Mu Chen, Chien-Hung Chin, Ting-Ya Wang, Jen-Chieh Chang, Yong-Yong Lin, Chiu-Ping Lee, Meng-Chih Lin
Format: Article
Language:English
Published: BMC 2023-02-01
Series:European Journal of Medical Research
Subjects:
Obstructive sleep apnea
Autophagy
DNA methylation
Mesenchymal stem cell
Intermittent hypoxia with re-oxygenation
Rapamycin
Online Access:https://doi.org/10.1186/s40001-023-01051-4

Internet

https://doi.org/10.1186/s40001-023-01051-4

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