Detection of viable SARS-CoV-2 in deep respiratory specimens despite negative nasopharyngeal SARS-CoV-2 RT-PCR: Occult COVID-19 as an unsuspected cause of pulmonary infiltrates in immunocompromised patients

Detection of viable SARS-CoV-2 in deep respiratory specimens despite negative nasopharyngeal SARS-CoV-2 RT-PCR: Occult COVID-19 as an unsuspected cause of pulmonary infiltrates in immunocompromised patients

Background: Prolonged shedding/relapse of COVID-19 infection has been reported, particularly in patients who received anti-CD20 agents (eg. rituximab). However, cases of occult COVID-19, in which SARS-CoV-2 persistence in lung parenchyma is diagnosed despite clearance from nasopharyngeal (NP) specim...

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Bibliographic Details
Main Authors: Liang En Wee, Jing Yuan Tan, Karrie Kwan-Ki Ko, Wei Yee Wan, Deborah Chooi Mun Lai, Lynette Lin Ean Oon, Alfonso Tan-Garcia, Joe Poh Sheng Yeong, Angela Maria Takano Pena, Tony Kiat Hon Lim, Edwin Philip Conceicao, Indumathi Venkatachalam, Limin Wijaya, Thuan Tong Tan
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:IDCases
Subjects:
SARS-CoV-2
COVID-19
Viral antigen
Relapse
Immunocompromise
Rituximab
Online Access:http://www.sciencedirect.com/science/article/pii/S2214250922002396

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http://www.sciencedirect.com/science/article/pii/S2214250922002396

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