CYP27A1-27-hydroxycholesterol axis in the respiratory system contributes to house dust mite-induced allergic airway inflammation

CYP27A1-27-hydroxycholesterol axis in the respiratory system contributes to house dust mite-induced allergic airway inflammation

Background: 27-Hydroxycholesterol (27-HC) derived from sterol 27-hydroxylase (CYP27A1) has pro-inflammatory biological activity and is associated with oxidative stress and chronic inflammation in COPD. However, the role of regulation of CYP27A1- 27-HC axis in asthma is unclear. This study aimed to e...

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Bibliographic Details
Main Authors: Tatsunori Ito, Tomohiro Ichikawa, Mitsuhiro Yamada, Yuichiro Hashimoto, Naoya Fujino, Tadahisa Numakura, Yusaku Sasaki, Ayumi Suzuki, Katsuya Takita, Hirohito Sano, Yorihiko Kyogoku, Takuya Saito, Akira Koarai, Tsutomu Tamada, Hisatoshi Sugiura
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Allergology International
Subjects:
Asthma
CYP27A1
Eosinophils
Oxysterols
27-Hydroxycholesterol
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893023000813

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http://www.sciencedirect.com/science/article/pii/S1323893023000813

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