The Pattern of Methylation and Polymorphism in Interleukin-6 Promoter Gene Are Related to the Development of Rheumatoid Arthritis?

The Pattern of Methylation and Polymorphism in Interleukin-6 Promoter Gene Are Related to the Development of Rheumatoid Arthritis?

Rheumatoid Arthritis (RA) is a complex disease with higher level of IL-6. In order to elucidate the alterations related to IL-6 gene in RA, we evaluated the -174 G/C IL-6 gene polymorphism and methylation pattern of its promoter. A total of 120 RA patients and 120 healthy controls were recruited for...

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Bibliographic Details
Main Authors: Isaura Isabelle Fonseca Gomes-Silva, Eliezer Rushansky, Francisco Geraldo Carvalho-Neto, Amanda Virginia Batista Vieira, Maria Helena Queiroz de Araujo Mariano, Paulo Roberto Eleutério de Souza, Martín Alejandro Montes, Maria Mascena Diniz Maia
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2018-08-01
Series:Acta Medica Iranica
Subjects:
Cytokine
Inflammation
Epigenetics
MSP-PCR
Single nucleotide polymorphism
Online Access:https://acta.tums.ac.ir/index.php/acta/article/view/6344

Internet

https://acta.tums.ac.ir/index.php/acta/article/view/6344

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