Loss of Function of WFS1 Causes ER Stress-Mediated Inflammation in Pancreatic Beta-Cells

Loss of Function of WFS1 Causes ER Stress-Mediated Inflammation in Pancreatic Beta-Cells

Wolfram syndrome is a rare genetic disorder characterized by juvenile-onset diabetes mellitus, optic nerve atrophy, hearing loss, diabetes insipidus, and progressive neurodegeneration. Pathogenic variants in the WFS1 gene are the main causes of Wolfram syndrome. WFS1 encodes a transmembrane protein...

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Bibliographic Details
Main Authors: Shuntaro Morikawa, Lindsey Blacher, Chinyere Onwumere, Fumihiko Urano
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Endocrinology
Subjects:
Wolfram syndrome
inflammation
diabetes
macrophage
endoplasmic reticulum stress
unfolded protein response
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.849204/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.849204/full

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