CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells

CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells

ABSTRACTBackground and Purpose Substitution of Cys674 (C674) in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) causes SERCA2 dysfunction which leads to activated inositol requiring enzyme 1 alpha (IRE1α) and spliced X-box binding protein 1 (XBP1s) pathway accelerating cell proliferati...

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Bibliographic Details
Main Authors: Weimin Yu, Qian Zhang, Yixiang Qiu, Hui Chen, Xiaoyang Huang, Li Xiao, Gang Xu, Siqi Li, Pingping Hu, Xiaoyong Tong
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Clinical and Experimental Hypertension
Subjects:
Pulmonary hypertension
SERCA2
pulmonary vascular remodeling
pulmonary artery smooth muscle cells; phenotypic transition
calcineurin
nuclear factor of activated T-lymphocytes
Online Access:https://www.tandfonline.com/doi/10.1080/10641963.2023.2272062

Internet

https://www.tandfonline.com/doi/10.1080/10641963.2023.2272062

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