Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression

Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression

Endometriosis is a common gynecological disease, characterized by the presence of endometrial-like lesions outside the uterus. This debilitating disease causes chronic pelvic pain and infertility with limited therapeutics. Chemerin is a secretory protein that acts on CMKLR1 (Chemokine-Like Receptor...

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Bibliographic Details
Main Authors: Ming Yu, Yali Yang, Hao Zhao, Mengxia Li, Jie Chen, Baobei Wang, Tianxia Xiao, Chen Huang, Huashan Zhao, Wei Zhou, Jian V. Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
endometriosis
chemerin
CMKLR1
small molecule antagonist
α-NETA
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.985618/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.985618/full

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