High expression of serine and arginine-rich splicing factor 9 (SRSF9) is associated with hepatocellular carcinoma progression and a poor prognosis
Highlights SRSF9 is a potential independent risk factor for HCC. High methylation status of cg06116271 predicted a better prognosis in HCC. SRSF9 knockdown inhibited the Wnt signaling pathway and cell cycle pathway. SRSF9 may serve as a potential therapeutic target for HCC.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-08-01
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| Series: | BMC Medical Genomics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12920-022-01316-7 |
| _version_ | 1818498025530589184 |
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| author | Guoshun Zhang Bin Liu Hua Shang Guikai Wu Diyang Wu Liuqing Wang Shengnan Li Zhiyuan Wang Suying Wang Juxiang Yuan |
| author_facet | Guoshun Zhang Bin Liu Hua Shang Guikai Wu Diyang Wu Liuqing Wang Shengnan Li Zhiyuan Wang Suying Wang Juxiang Yuan |
| author_sort | Guoshun Zhang |
| collection | DOAJ |
| description | Highlights SRSF9 is a potential independent risk factor for HCC. High methylation status of cg06116271 predicted a better prognosis in HCC. SRSF9 knockdown inhibited the Wnt signaling pathway and cell cycle pathway. SRSF9 may serve as a potential therapeutic target for HCC. |
| first_indexed | 2024-12-10T18:52:41Z |
| format | Article |
| id | doaj.art-82d0ce5fcc634b2b8a87205884584b47 |
| institution | Directory Open Access Journal |
| issn | 1755-8794 |
| language | English |
| last_indexed | 2024-12-10T18:52:41Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genomics |
| spelling | doaj.art-82d0ce5fcc634b2b8a87205884584b472022-12-22T01:37:16ZengBMCBMC Medical Genomics1755-87942022-08-0115111110.1186/s12920-022-01316-7High expression of serine and arginine-rich splicing factor 9 (SRSF9) is associated with hepatocellular carcinoma progression and a poor prognosisGuoshun Zhang0Bin Liu1Hua Shang2Guikai Wu3Diyang Wu4Liuqing Wang5Shengnan Li6Zhiyuan Wang7Suying Wang8Juxiang Yuan9School of Public Health, North China University of Science and TechnologyDepartment of Gastroenterology, Chaisang District People’s HospitalBlood Purification Department of Tangshan Infectious Disease HospitalDepartment of Gastroenterology, Tangshan Workers’ HospitalDepartment of Gastroenterology, Tangshan Workers’ HospitalDepartment of Gastroenterology, Hongci HospitalDepartment of Gastroenterology, Affiliated Hospital of North China University of TechnologyDepartment of Gastroenterology, Affiliated Hospital of North China University of TechnologyDepartment of Gastroenterology, Affiliated Hospital of North China University of TechnologySchool of Public Health, North China University of Science and TechnologyHighlights SRSF9 is a potential independent risk factor for HCC. High methylation status of cg06116271 predicted a better prognosis in HCC. SRSF9 knockdown inhibited the Wnt signaling pathway and cell cycle pathway. SRSF9 may serve as a potential therapeutic target for HCC.https://doi.org/10.1186/s12920-022-01316-7SRSF9Hepatocellular carcinomaBiomarkerscg06116271Prognosis |
| spellingShingle | Guoshun Zhang Bin Liu Hua Shang Guikai Wu Diyang Wu Liuqing Wang Shengnan Li Zhiyuan Wang Suying Wang Juxiang Yuan High expression of serine and arginine-rich splicing factor 9 (SRSF9) is associated with hepatocellular carcinoma progression and a poor prognosis BMC Medical Genomics SRSF9 Hepatocellular carcinoma Biomarkers cg06116271 Prognosis |
| title | High expression of serine and arginine-rich splicing factor 9 (SRSF9) is associated with hepatocellular carcinoma progression and a poor prognosis |
| title_full | High expression of serine and arginine-rich splicing factor 9 (SRSF9) is associated with hepatocellular carcinoma progression and a poor prognosis |
| title_fullStr | High expression of serine and arginine-rich splicing factor 9 (SRSF9) is associated with hepatocellular carcinoma progression and a poor prognosis |
| title_full_unstemmed | High expression of serine and arginine-rich splicing factor 9 (SRSF9) is associated with hepatocellular carcinoma progression and a poor prognosis |
| title_short | High expression of serine and arginine-rich splicing factor 9 (SRSF9) is associated with hepatocellular carcinoma progression and a poor prognosis |
| title_sort | high expression of serine and arginine rich splicing factor 9 srsf9 is associated with hepatocellular carcinoma progression and a poor prognosis |
| topic | SRSF9 Hepatocellular carcinoma Biomarkers cg06116271 Prognosis |
| url | https://doi.org/10.1186/s12920-022-01316-7 |
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