Targeting the Histone Methyltransferase Disruptor of Telomeric Silencing 1-Like Restricts Avian Leukosis Virus Subgroup J Replication by Restoring the Innate Immune Response in Chicken Macrophages

Targeting the Histone Methyltransferase Disruptor of Telomeric Silencing 1-Like Restricts Avian Leukosis Virus Subgroup J Replication by Restoring the Innate Immune Response in Chicken Macrophages

Avian leukosis virus subgroup J (ALV-J), an oncogenic retrovirus, is known to cause immunosuppression and various types of cancer in chickens. Recent reports have shown that epigenetic changes in DNA and chromatin are widely implicated in the life cycle of diverse viruses, and reversal of these chan...

Full description

Bibliographic Details
Main Authors: Shihao Chen, Dedong Wang, Yinyin Liu, Ruihan Zhao, Ting Wu, Xuming Hu, Zhiming Pan, Hengmi Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Microbiology
Subjects:
DOT1L
ALV-J
innate immunity
MDA5
chicken macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.603131/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2020.603131/full

Similar Items