Valvular Cardiomyopathy in Aortic Valve Regurgitation Correlates with Myocardial Fibrosis

Valvular Cardiomyopathy in Aortic Valve Regurgitation Correlates with Myocardial Fibrosis

<b>Objective:</b> At the tissue level, disruption of the extracellular matrix network leads to irreversible cardiac fibrosis, which contributes to myocardial dysfunction. At the myocyte level, downregulation of beta-adrenoceptors (beta-AR) reduces adaptation to increased workload. The ai...

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Bibliographic Details
Main Authors: Johannes Petersen, Shahria Iqbal, Naomi Gedeon, Benjamin Kloth, Simon Pecha, Yalin Yildirim, Thomas Eschenhagen, Hermann Reichenspurner, Torsten Christ, Evaldas Girdauskas
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Journal of Clinical Medicine
Subjects:
valvular cardiomyopathy
myocardial fibrosis
aortic valve disease
aortic regurgitation
Online Access:https://www.mdpi.com/2077-0383/12/8/2915

Internet

https://www.mdpi.com/2077-0383/12/8/2915

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