Studying the Effect of MBNL1 and MBNL2 Loss in Skeletal Muscle Regeneration

Studying the Effect of MBNL1 and MBNL2 Loss in Skeletal Muscle Regeneration

Loss of function of members of the muscleblind-like (MBNL) family of RNA binding proteins has been shown to play a key role in the spliceopathy of RNA toxicity in myotonic dystrophy type 1 (DM1), the most common muscular dystrophy affecting adults and children. MBNL1 and MBNL2 are the most abundantl...

Full description

Bibliographic Details
Main Authors:	Ramesh S. Yadava, Mahua Mandal, Mani S. Mahadevan
Format:	Article
Language:	English
Published:	MDPI AG 2024-02-01
Series:	International Journal of Molecular Sciences
Subjects:	muscle regeneration myotonic dystrophy RNA toxicity satellite cells muscleblind RNA binding proteins
Online Access:	https://www.mdpi.com/1422-0067/25/5/2687

Similar Items

BlockmiR AONs as Site-Specific Therapeutic MBNL Modulation in Myotonic Dystrophy 2D and 3D Muscle Cells and HSA<sup>LR</sup> Mice
by: Sarah J. Overby, et al.
Published: (2023-03-01)

Proof of concept of peptide-linked blockmiR-induced MBNL functional rescue in myotonic dystrophy type 1 mouse model
by: Sarah J. Overby, et al.
Published: (2022-03-01)

(CCUG)n RNA toxicity in a Drosophila model of myotonic dystrophy type 2 (DM2) activates apoptosis
by: Vildan Betul Yenigun, et al.
Published: (2017-08-01)

Cardiac Pathology in Myotonic Dystrophy Type 1
by: Mani S. Mahadevan, et al.
Published: (2021-11-01)

Pentamidine rescues contractility and rhythmicity in a Drosophila model of myotonic dystrophy heart dysfunction
by: Mouli Chakraborty, et al.
Published: (2015-12-01)

Loss of MBNL1-mediated retrograde BDNF signaling in the myotonic dystrophy brain
by: Pei-Ying Wang, et al.
Published: (2023-03-01)

Cognate RNA-Binding Modes by the Alternative-Splicing Regulator MBNL1 Inferred from Molecular Dynamics
by: Àlex L. González, et al.
Published: (2022-12-01)

An unusual case with myotonia
by: Yu-Wei Da, et al.
Published: (2013-03-01)

LDB3 splicing abnormalities are specific to skeletal muscles of patients with myotonic dystrophy type 1 and alter its PKC binding affinity
by: Yoshihiro Yamashita, et al.
Published: (2014-09-01)

Zebrafish mbnl mutants model physical and molecular phenotypes of myotonic dystrophy
by: Melissa N. Hinman, et al.
Published: (2021-06-01)

Calcitriol increases MBNL1 expression and alleviates myotonic dystrophy phenotypes in HSALR mouse models
by: Kun Huang, et al.
Published: (2022-12-01)

microRNA-mRNA Profile of Skeletal Muscle Differentiation and Relevance to Congenital Myotonic Dystrophy
by: Sarah U. Morton, et al.
Published: (2021-03-01)

Sustainable recovery of MBNL activity in autoregulatory feedback loop in myotonic dystrophy
by: Zuzanna Rogalska, et al.
Published: (2022-12-01)

Deprivation of Muscleblind-Like Proteins Causes Deficits in Cortical Neuron Distribution and Morphological Changes in Dendritic Spines and Postsynaptic Densities
by: Kuang-Yung Lee, et al.
Published: (2019-07-01)

Erythromycin for myotonic dystrophy type 1: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trialResearch in context
by: Masayuki Nakamori, et al.
Published: (2024-01-01)

MiRNAs and Muscle Regeneration: Therapeutic Targets in Duchenne Muscular Dystrophy
by: Amelia Eva Aránega, et al.
Published: (2021-04-01)

Abnormalities in Skeletal Muscle Myogenesis, Growth, and Regeneration in Myotonic Dystrophy
by: Laurène M. André, et al.
Published: (2018-05-01)

Muscle wasting in myotonic dystrophies: a model of premature aging.
by: Alba Judith eMateos-Aierdi, et al.
Published: (2015-07-01)

Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression
by: Irene González-Martínez, et al.
Published: (2023-12-01)

Small Molecules Which Improve Pathogenesis of Myotonic Dystrophy Type 1
by: Marta López-Morató, et al.
Published: (2018-05-01)

Skeletal muscle in health and disease
by: Jennifer Morgan, et al.
Published: (2020-02-01)

Muscleblind-Like 1 and Muscleblind-Like 3 Depletion Synergistically Enhances Myotonia by Altering Clc-1 RNA Translation
by: Jongkyu Choi, et al.
Published: (2015-09-01)

Skeletal muscle features in myotonic dystrophy and sarcopenia: do similar nuclear mechanisms lead to skeletal muscle wasting?
by: M. Malatesta
Published: (2012-08-01)

HDAC4 Regulates Skeletal Muscle Regeneration via Soluble Factors
by: Alessandra Renzini, et al.
Published: (2018-09-01)

Orexin/hypocretin levels in the cerebrospinal fluid and characteristics of patients with myotonic dystrophy type 1 with excessive daytime sleepiness
by: Omori Y, et al.
Published: (2018-02-01)

MBNL2 Regulates DNA Damage Response via Stabilizing p21
by: Jin Cai, et al.
Published: (2021-01-01)

RNA-Binding Proteins in the Post-transcriptional Control of Skeletal Muscle Development, Regeneration and Disease
by: De-Li Shi, et al.
Published: (2021-09-01)

Targeting DMPK with Antisense Oligonucleotide Improves Muscle Strength in Myotonic Dystrophy Type 1 Mice
by: Dominic Jauvin, et al.
Published: (2017-06-01)

Structural and functional alterations of the cell nucleus in skeletal muscle wasting: the evidence in situ
by: M. Malatesta, et al.
Published: (2010-10-01)

Aberrant splicing and expression of the non muscle myosin heavy-chain gene MYH14 in DM1 muscle tissues
by: F. Rinaldi, et al.
Published: (2012-01-01)

Regulation of Satellite Cells Functions during Skeletal Muscle Regeneration: A Critical Step in Physiological and Pathological Conditions
by: Giorgia Careccia, et al.
Published: (2023-12-01)

Mbnl1 and Mbnl2 regulate brain structural integrity in mice
by: Naomi S. Sta Maria, et al.
Published: (2021-11-01)

Development of Therapeutic Approaches for Myotonic Dystrophies Type 1 and Type 2
by: Lubov Timchenko
Published: (2022-09-01)

Exercise and skeletal muscle regeneration
by: Mitsutoshi Kurosaka, et al.
Published: (2012-10-01)

TNNT2 Missplicing in Skeletal Muscle as a Cardiac Biomarker in Myotonic Dystrophy Type 1 but Not in Myotonic Dystrophy Type 2
by: Francesca Bosè, et al.
Published: (2019-09-01)

A Patient with Myotonic Dystrophy Type 1 Presenting as Parkinsonism
by: Ji-Hyun Choi, et al.
Published: (2018-09-01)

Engineered skeletal muscle recapitulates human muscle development, regeneration and dystrophy
by: Mina Shahriyari, et al.
Published: (2022-12-01)

Methods for Accurate Assessment of Myofiber Maturity During Skeletal Muscle Regeneration
by: Yuki Yoshimoto, et al.
Published: (2020-04-01)

Bioengineered human skeletal muscle capable of functional regeneration
by: J. W. Fleming, et al.
Published: (2020-10-01)

Editorial: Frontiers in Skeletal Muscle Wasting, Regeneration and Stem Cells
by: Carlos Hermano J. ePinheiro, et al.
Published: (2015-05-01)