Influence of subject discontinuation on long-term nonvertebral fracture rate in the denosumab FREEDOM Extension study

Influence of subject discontinuation on long-term nonvertebral fracture rate in the denosumab FREEDOM Extension study

Abstract Background Denosumab treatment for up to 8 years in the FREEDOM study and Extension was associated with low fracture incidence. It was not clear whether subjects who discontinued during the study conduct had a higher risk of fracture than those who remained enrolled, thereby underestimating...

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Bibliographic Details
Main Authors: Jonathan D. Adachi, Henry G. Bone, Nadia S. Daizadeh, Paula Dakin, Socrates Papapoulos, Peyman Hadji, Chris Recknor, Michael A. Bolognese, Andrea Wang, Celia J. F. Lin, Rachel B. Wagman, Serge Ferrari
Format: Article
Language:English
Published: BMC 2017-04-01
Series:BMC Musculoskeletal Disorders
Subjects:
Denosumab
Osteoporosis
Selection bias
Extension study
FREEDOM
Online Access:http://link.springer.com/article/10.1186/s12891-017-1520-6

Internet

http://link.springer.com/article/10.1186/s12891-017-1520-6

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