Investigation of Marine-Derived Natural Products as Raf Kinase Inhibitory Protein (RKIP)-Binding Ligands

Investigation of Marine-Derived Natural Products as Raf Kinase Inhibitory Protein (RKIP)-Binding Ligands

Raf kinase inhibitory protein (RKIP) is an essential regulator of the Ras/Raf-1/MEK/ERK signaling cascade and functions by directly interacting with the Raf-1 kinase. The abnormal expression of RKIP is linked with numerous diseases including cancers, Alzheimer’s and diabetic nephropathy. Interesting...

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Bibliographic Details
Main Authors: Shraddha Parate, Vikas Kumar, Jong Chan Hong, Keun Woo Lee
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Marine Drugs
Subjects:
RKIP
marine natural products
pharmacophore modeling
virtual screening
molecular docking
molecular dynamics simulations
Online Access:https://www.mdpi.com/1660-3397/19/10/581

Internet

https://www.mdpi.com/1660-3397/19/10/581

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