β-Lapachone ameliorates lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice.

β-Lapachone ameliorates lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice.

Lipotoxic cardiomyopathy is caused by myocardial lipid accumulation and often occurs in patients with diabetes and obesity. This study investigated the effects of β-lapachone (β-lap), a natural compound that activates Sirt1 through elevation of the intracellular NAD+ level, on acyl CoA synthase (ACS...

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Bibliographic Details
Main Authors: Moon Hee Jeong, Nguyen Khoi Song Tran, Tae Hwan Kwak, Byung Keon Park, Chul Soon Lee, Tae-Sik Park, Young-Hoon Lee, Woo Jin Park, Dong Kwon Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3948739?pdf=render

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http://europepmc.org/articles/PMC3948739?pdf=render

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