Anticancer activity of Aucklandia costus Falc. terpenes: Targeting MDM2 protein inhibition for therapeutic advancements

Anticancer activity of Aucklandia costus Falc. terpenes: Targeting MDM2 protein inhibition for therapeutic advancements

Context: Protein 53 (p53) is a well-known tumor suppressor protein, while murine double minute 2 (MDM2) acts as a negative regulator of p53, leading to p53 inactivation and cancer development. Aucklandia costus Falc. or Saussurea lappa contains bioactive compounds, particularly terpenoids, known for...

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Bibliographic Details
Main Authors: Theresia Indah Budhy, Ira Arundina, Anis Irmawati, Sidarningsih, Meircurius Dwi Condro Surboyo, Cecillia Octavianni Raharjo, Ciptantyo Septyan Akbar, Malika Qadira Rahmalia
Format: Article
Language:English
Published: GarVal Editorial Ltda. 2024-07-01
Series:Journal of Pharmacy & Pharmacognosy Research
Subjects:
admet
aucklandia costus
cancer
docking
mdm2
saussurea lappa
Online Access:https://jppres.com/jppres/pdf/vol12/jppres23.1910_12.4.748.pdf

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https://jppres.com/jppres/pdf/vol12/jppres23.1910_12.4.748.pdf

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