Repurposing thioridazine for inducing immunogenic cell death in colorectal cancer via eIF2α/ATF4/CHOP and secretory autophagy pathways

Repurposing thioridazine for inducing immunogenic cell death in colorectal cancer via eIF2α/ATF4/CHOP and secretory autophagy pathways

Abstract Background Colorectal cancer (CRC) is a highly prevalent cancer type with limited targeted therapies available and 5-year survival rate, particularly for late-stage patients. There have been numerous attempts to repurpose drugs to tackle this problem. It has been reported that autophagy ind...

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Bibliographic Details
Main Authors: Thu-Ha Tran, Ming Kao, Hsiao-Sheng Liu, Yi-Ren Hong, Yeu Su, Chi-Ying F. Huang
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Cell Communication and Signaling
Subjects:
Colorectal cancer
Thioridazine
Immunogenic cell death
Endoplasmic reticulum stress
Secretory autophagy
Online Access:https://doi.org/10.1186/s12964-023-01190-5

Internet

https://doi.org/10.1186/s12964-023-01190-5

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