Discovery of dual rho-associated protein kinase 1 (ROCK1)/apoptosis signal–regulating kinase 1 (ASK1) inhibitors as a novel approach for non-alcoholic steatohepatitis (NASH) treatment

Discovery of dual rho-associated protein kinase 1 (ROCK1)/apoptosis signal–regulating kinase 1 (ASK1) inhibitors as a novel approach for non-alcoholic steatohepatitis (NASH) treatment

Abstract In the current study we suggest a novel approach to curb non-alcoholic steatohepatitis (NASH) progression, and we suggest privileged scaffolds for the design of novel compounds for this aim. NASH is an advanced form of non-alcoholic fatty liver disease that can further progress into fibrosi...

Full description

Bibliographic Details
Main Authors: Yara A. Zaky, Mai W. Rashad, Marwa A. Zaater, Ahmed M. El Kerdawy
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Chemistry
Subjects:
NASH
ASK1
MAP3K5
ROCK1
Pharmacophore modeling
Molecular docking
Online Access:https://doi.org/10.1186/s13065-023-01081-3

Internet

https://doi.org/10.1186/s13065-023-01081-3

Similar Items