Discovery of dual rho-associated protein kinase 1 (ROCK1)/apoptosis signal–regulating kinase 1 (ASK1) inhibitors as a novel approach for non-alcoholic steatohepatitis (NASH) treatment
Abstract In the current study we suggest a novel approach to curb non-alcoholic steatohepatitis (NASH) progression, and we suggest privileged scaffolds for the design of novel compounds for this aim. NASH is an advanced form of non-alcoholic fatty liver disease that can further progress into fibrosi...
Main Authors: | Yara A. Zaky, Mai W. Rashad, Marwa A. Zaater, Ahmed M. El Kerdawy |
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Format: | Article |
Language: | English |
Published: |
BMC
2024-01-01
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Series: | BMC Chemistry |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13065-023-01081-3 |
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