Case report: Stem cell-based suicide gene therapy mediated by the herpes simplex virus thymidine kinase gene reduces tumor progression in multifocal glioblastoma

Case report: Stem cell-based suicide gene therapy mediated by the herpes simplex virus thymidine kinase gene reduces tumor progression in multifocal glioblastoma

IntroductionThe prognosis for glioblastoma multiforme (GBM), a malignant brain tumor, is poor despite recent advancements in treatments. Suicide gene therapy is a therapeutic strategy for cancer that requires a gene to encode a prodrug-activating enzyme which is then transduced into a vector, such a...

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Bibliographic Details
Main Authors: Saeed Oraee-Yazdani, Mohammadhosein Akhlaghpasand, Fatemeh Rostami, Maryam Golmohammadi, Roozbeh Tavanaei, Gelareh Shokri, Maryam Hafizi, Maryam Oraee-Yazdani, Ali-Reza Zali, Masoud Soleimani
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Neurology
Subjects:
multifocal glioblastoma
suicide gene therapy (SGT)
stem cell gene therapy
HSV thymidine kinase
cell and gene therapies
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2023.1060180/full

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https://www.frontiersin.org/articles/10.3389/fneur.2023.1060180/full

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