Hemophilia A Inhibitor Subjects Show Unique PBMC Gene Expression Profiles That Include Up-Regulated Innate Immune Modulators

Hemophilia A Inhibitor Subjects Show Unique PBMC Gene Expression Profiles That Include Up-Regulated Innate Immune Modulators

Formation of pathological anti-FVIII antibodies, or “inhibitors,” is the most serious complication of therapeutic FVIII infusions, affecting up to 1/3 of severe Hemophilia A (HA) patients. Inhibitor formation is a classical T-cell dependent adaptive immune response. As such, it requires help from th...

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Bibliographic Details
Main Authors: Ahmad Faisal Karim, Anthony R. Soltis, Gauthaman Sukumar, Christoph Königs, Nadia P. Ewing, Clifton L. Dalgard, Matthew D. Wilkerson, Kathleen P. Pratt
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
hemophilia A
RNAseq analysis
innate and adaptive immune response
factor VIII (FVIII)
PBMC (peripheral blood mononuclear cells)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01219/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.01219/full

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