Cystathionine-β-Synthase Inhibition for Colon Cancer: Enhancement of the Efficacy of Aminooxyacetic Acid via the Prodrug Approach

Cystathionine-β-Synthase Inhibition for Colon Cancer: Enhancement of the Efficacy of Aminooxyacetic Acid via the Prodrug Approach

Abstract Colon cancer cells contain high levels of cystathlonlne-β-synthase (CBS). Its product, hydrogen sulfide (H2S), promotes the growth and proliferation of colorectal tumor cells. To improve the antitumor efficacy of the prototypical CBS inhibitor aminooxyacetic acid (AOAA), we have designed an...

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Bibliographic Details
Main Authors: Celia Chao, John R Zatarain, Ye Ding, Ciro Coletta, Amy A Mrazek, Nadiya Druzhyna, Paul Johnson, Haiying Chen, Judy L Hellmich, Antonia Asimakopoulou, Kazunori Yanagi, Gabor Olah, Petra Szoleczky, Gabor Törö, Fredrick J Bohanon, Minal Cheema, Rachel Lewis, David Eckelbarger, Akbar Ahmad, Katalin Módis, Ashley Untereiner, Bartosz Szczesny, Andreas Papapetropoulos, Jia Zhou, Mark R Hellmich, Csaba Szabo
Format: Article
Language:English
Published: BMC 2016-05-01
Series:Molecular Medicine
Online Access:http://link.springer.com/article/10.2119/molmed.2016.00102

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http://link.springer.com/article/10.2119/molmed.2016.00102

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