Generation and characterization of NGLY1 patient-derived midbrain organoids

Generation and characterization of NGLY1 patient-derived midbrain organoids

NGLY1 deficiency is an ultra-rare, autosomal recessive genetic disease caused by mutations in the NGLY1 gene encoding N-glycanase one that removes N-linked glycan. Patients with pathogenic mutations in NGLY1 have complex clinical symptoms including global developmental delay, motor disorder and live...

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Bibliographic Details
Main Authors: Joshua Abbott, Mitali Tambe, Ivan Pavlinov, Atena Farkhondeh, Ha Nam Nguyen, Miao Xu, Manisha Pradhan, Tate York, Matthew Might, Karsten Baumgärtel, Steven Rodems, Wei Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
NGLY1
midbrain organoids
dopaminergic neurons
GABA
GFAP
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1039182/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1039182/full

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