Hippocampal Excitatory Synaptic Transmission and Plasticity Are Differentially Altered during Postnatal Development by Loss of the X-Linked Intellectual Disability Protein Oligophrenin-1

Hippocampal Excitatory Synaptic Transmission and Plasticity Are Differentially Altered during Postnatal Development by Loss of the X-Linked Intellectual Disability Protein Oligophrenin-1

Oligophrenin-1 (OPHN1) is a Rho-GTPase-activating protein (RhoGAP), whose mutations are associated with X-linked intellectual disability (XLID). OPHN1 is enriched at the synapse in both pre- and postsynaptic compartments, where it regulates the RhoA/ROCK/MLC2 signaling pathway, playing a critical ro...

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Bibliographic Details
Main Authors: Noemie Cresto, Nicolas Lebrun, Florent Dumont, Franck Letourneur, Pierre Billuart, Nathalie Rouach
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cells
Subjects:
intellectual disability
Oligophrenin-1
synaptic transmission
plasticity
hippocampus
development
Online Access:https://www.mdpi.com/2073-4409/11/9/1545

Internet

https://www.mdpi.com/2073-4409/11/9/1545

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