RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis

Abstract A core pathophysiologic feature underlying many respiratory diseases is multiciliated cell dysfunction, leading to inadequate mucociliary clearance. Due to the prevalence and highly variable etiology of mucociliary dysfunction in respiratory diseases, it is critical to understand the mechan...

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Bibliographic Details
Main Authors: Erik J. Quiroz, Seongjae Kim, Lalit K. Gautam, Zea Borok, Christopher Kintner, Amy L. Ryan
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06440-z