TNFα promotes oral cancer growth, pain, and Schwann cell activation

Abstract Oral cancer is very painful and impairs a patient’s ability to eat, talk, and drink. Mediators secreted from oral cancer can excite and sensitize sensory neurons inducing pain. Cancer mediators can also activate Schwann cells, the peripheral glia that regulates neuronal function and repair....

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Bibliographic Details
Main Authors: Elizabeth Salvo, Nguyen H. Tu, Nicole N. Scheff, Zinaida A. Dubeykovskaya, Shruti A. Chavan, Bradley E. Aouizerat, Yi Ye
Format: Article
Language:English
Published: Nature Portfolio 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-81500-4