Conditioned pain modulation is associated with common polymorphisms in the serotonin transporter gene.

BACKGROUND: Variation in the serotonin transporter (5-HTT) gene (SLC6A4) has been shown to influence a wide range of affective processes. Low 5-HTT gene-expression has also been suggested to increase the risk of chronic pain. Conditioned pain modulation (CPM)--i.e. 'pain inhibits pain'--is...

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Bibliographic Details
Main Authors: Fredrik Lindstedt, Jonathan Berrebi, Erik Greayer, Tina B Lonsdorf, Martin Schalling, Martin Ingvar, Eva Kosek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3065474?pdf=render