Repurposing Glutathione Transferases: Directed Evolution Combined with Chemical Modification for the Creation of a Semisynthetic Enzyme with High Hydroperoxidase Activity

Repurposing Glutathione Transferases: Directed Evolution Combined with Chemical Modification for the Creation of a Semisynthetic Enzyme with High Hydroperoxidase Activity

Glutathione peroxidases (GPXs) are antioxidant selenoenzymes, which catalyze the reduction of hydroperoxides via glutathione (GSH), providing protection to cells against oxidative stress metabolites. The present study aims to create an efficient semisynthetic GPX based on the scaffold of tau class g...

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Bibliographic Details
Main Authors: Irene Axarli, Farid Ataya, Nikolaos E. Labrou
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Antioxidants
Subjects:
chemical modification
directed evolution
enzyme engineering
glutathione transferase
glutathione peroxidase
Online Access:https://www.mdpi.com/2076-3921/13/1/41

Internet

https://www.mdpi.com/2076-3921/13/1/41

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