A novel GPI-anchored dominant-negative TGF-β receptor II renders T cells unresponsive to TGF-β signaling

A novel GPI-anchored dominant-negative TGF-β receptor II renders T cells unresponsive to TGF-β signaling

Transforming growth factor β (TGF-β) is a pleiotropic cytokine expressed by a wide range of cell types and is known for hampering the effectiveness of cancer immune cell therapeutic approaches. We have designed a novel construct containing the extracellular domain of the TGF-β receptor II linked to...

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Bibliographic Details
Main Authors: Sven H. Petersen, Kays Al Badawy, Richard Hopkins, Dang L. Vu, Mehran Rahmani, Sonia M.P. Maia, John E. Connolly
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
tumor growth factor beta
TGF-β
decoy receptor
cell therapy
T cell
cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770523000797

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http://www.sciencedirect.com/science/article/pii/S2372770523000797

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