Rational Design of Cyclic Antimicrobial Peptides Based on BPC194 and BPC198

Rational Design of Cyclic Antimicrobial Peptides Based on BPC194 and BPC198

A strategy for the design of antimicrobial cyclic peptides derived from the lead compounds c(KKLKKFKKLQ) (BPC194) and c(KLKKKFKKLQ) (BPC198) is reported. First, the secondary β-structure of BPC194 and BPC198 was analyzed by carrying out molecular dynamics (MD) simulations. Then, based on the sequenc...

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Bibliographic Details
Main Authors: Anna D. Cirac, Maria Torné, Esther Badosa, Emilio Montesinos, Pedro Salvador, Lidia Feliu, Marta Planas
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Molecules
Subjects:
antimicrobial peptides
rational design
molecular dynamics
cyclopeptides
plant pathogens
secondary structure
Online Access:http://www.mdpi.com/1420-3049/22/7/1054

Internet

http://www.mdpi.com/1420-3049/22/7/1054

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