Distinct transcriptional responses to fludioxonil in Aspergillus fumigatus and its ΔtcsC and Δskn7 mutants reveal a crucial role for Skn7 in the cell wall reorganizations triggered by this antifungal

Distinct transcriptional responses to fludioxonil in Aspergillus fumigatus and its ΔtcsC and Δskn7 mutants reveal a crucial role for Skn7 in the cell wall reorganizations triggered by this antifungal

Abstract Background Aspergillus fumigatus is a major fungal pathogen that causes severe problems due to its increasing resistance to many therapeutic agents. Fludioxonil is a compound that triggers a lethal activation of the fungal-specific High Osmolarity Glycerol pathway. Its pronounced antifungal...

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Bibliographic Details
Main Authors: Sebastian Schruefer, Annica Pschibul, Sarah Sze Wah Wong, Tongta Sae-Ong, Thomas Wolf, Sascha Schäuble, Gianni Panagiotou, Axel A. Brakhage, Vishukumar Aimanianda, Olaf Kniemeyer, Frank Ebel
Format: Article
Language:English
Published: BMC 2023-11-01
Series:BMC Genomics
Subjects:
Aspergillus fumigatus
Fludioxonil
HOG pathway
Skn7
TcsC
Multistep phosphorelay
Online Access:https://doi.org/10.1186/s12864-023-09777-5

Internet

https://doi.org/10.1186/s12864-023-09777-5

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