Analysis of Pembrolizumab in Human Plasma by LC-MS/HRMS. Method Validation and Comparison with Elisa

Analysis of Pembrolizumab in Human Plasma by LC-MS/HRMS. Method Validation and Comparison with Elisa

Pembrolizumab is a humanized immunoglobulin G4-kappa anti-PD1 antibody used in the treatment of different solid tumors or haematological malignancies. A liquid chromatography coupled with a high resolution mass spectrometry (orbitrap technology) method was fully developed, optimized, and validated f...

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Bibliographic Details
Main Authors: Aurélien Millet, Nihel Khoudour, Jérôme Guitton, Dorothée Lebert, François Goldwasser, Benoit Blanchet, Christelle Machon
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Biomedicines
Subjects:
pembrolizumab
mass spectrometry
ELISA
therapeutic drug monitoring
Online Access:https://www.mdpi.com/2227-9059/9/6/621

Internet

https://www.mdpi.com/2227-9059/9/6/621

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