Sustaining the T-cell activity in xenografted psoriasis skin.

Xenografting of psoriasis skin onto immune deficient mice has been widely used to obtain proof-of-principle of new drug candidates. However, the lack of human T-cell activity in the grafts limits the use of the model. Here, we show that xenografting of lesional skin from psoriasis patients onto huma...

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Bibliographic Details
Main Authors: Pernille Kristine Fisker Christensen, Axel Kornerup Hansen, Søren Skov, Kåre Engkilde, Jesper Larsen, Maria Helena Høyer-Hansen, Janne Koch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0278390