Targeting Tat–TAR RNA Interaction for HIV-1 Inhibition

Targeting Tat–TAR RNA Interaction for HIV-1 Inhibition

The HIV-1 Tat protein interacts with TAR RNA and recruits CDK9/cyclin T1 and other host factors to induce HIV-1 transcription. Thus, Tat–TAR RNA interaction, which is unique for HIV-1, represents an attractive target for anti-HIV-1 therapeutics. To target Tat–TAR RNA interaction, we used a crystal s...

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Bibliographic Details
Main Authors: Awadh Alanazi, Andrey Ivanov, Namita Kumari, Xionghao Lin, Songping Wang, Dmytro Kovalskyy, Sergei Nekhai
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Viruses
Subjects:
HIV-1 transcription
HIV-1 Tat
TAR RNA
small molecule inhibitors
Online Access:https://www.mdpi.com/1999-4915/13/10/2004

Internet

https://www.mdpi.com/1999-4915/13/10/2004

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