B cell responses to HIV antigen are a potent correlate of viremia in HIV-1 infection and improve with PD-1 blockade.

B cell responses to HIV antigen are a potent correlate of viremia in HIV-1 infection and improve with PD-1 blockade.

Infection with Human Immunodeficiency Virus Type 1 (HIV-1) induces defects of both cellular and humoral immune responses. Impaired CD4+ T cell help and B cell dysfunction may partially explain the low frequency of broadly neutralizing antibodies in HIV-infected individuals. To understand the extent...

Full description

Bibliographic Details
Main Authors: Katherine J Nicholas, Emily K Zern, Louise Barnett, Rita M Smith, Shelly L Lorey, Courtney A Copeland, Shanmugalakshmi Sadagopal, Spyros A Kalams
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3865293?pdf=render

Internet

http://europepmc.org/articles/PMC3865293?pdf=render

Similar Items