Case report: HLA-haploidentical HSCT rescued with donor lymphocytes infusions in a patient with X-linked chronic granulomatous disease

Case report: HLA-haploidentical HSCT rescued with donor lymphocytes infusions in a patient with X-linked chronic granulomatous disease

Chronic granulomatous disease is an inborn error of immunity due to disrupted function of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This results in impaired respiratory burst of phagocytes and insufficient killing of bacteria and fungi. Patients with chronic granulomat...

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Bibliographic Details
Main Authors: Julia Scheiermann, Annette Künkele, Arend von Stackelberg, Angelika Eggert, Peter Lang, Felix Zirngibl, Luise Martin, Johannes Hubertus Schulte, Horst von Bernuth
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
chronic granulomatous disease
HLA-haploidentical hematopoietic stem cell transplantation
TCR alpha/beta+/CD19+ depleted peripheral blood HSCT
donor lymphocyte infusion (DLI)
graft verses host disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1042650/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1042650/full

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