Increased CaMKII activation and contrast changes of cardiac β1-and β3-Adrenergic signaling pathways in a humanized angiotensinogen model of hypertension

Increased CaMKII activation and contrast changes of cardiac β1-and β3-Adrenergic signaling pathways in a humanized angiotensinogen model of hypertension

Aims: Upregulation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) contributes to the pathogenesis of cardiovascular disease, including hypertension. Transgenic rats expressing the human angiotensinogen gene [TGR (hAGT)L1623] are a new novel humanized model of hypertension that associates wi...

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Bibliographic Details
Main Authors: Xiaoqiang Sun, Jing Cao, Zhe Chen, Yixi Liu, Jessica L. VonCannon, Heng Jie Cheng, Carlos M. Ferrario, Che Ping Cheng
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Heliyon
Subjects:
Calcium-calmodulin-dependent protein kinase type II
Hypertension
Cardiomyocyte
Transgenic models
β-adrenergic reserve
Angiotensinogen
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023050594

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http://www.sciencedirect.com/science/article/pii/S2405844023050594

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