Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice.

Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice.

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading known genetic cause of autism. Fragile X mental retardation protein (FMRP), which is absent or expressed at substantially reduced levels in FXS, binds to and controls the postsynaptic translation of...

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Main Authors: Cara J Westmark, Pamela R Westmark, Kenneth J O'Riordan, Brian C Ray, Crystal M Hervey, M Shahriar Salamat, Sara H Abozeid, Kelsey M Stein, Levi A Stodola, Michael Tranfaglia, Corinna Burger, Elizabeth M Berry-Kravis, James S Malter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3202540?pdf=render

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http://europepmc.org/articles/PMC3202540?pdf=render

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