Lymphocyte HVEM/BTLA co-expression after critical illness demonstrates severity indiscriminate upregulation, impacting critical illness-induced immunosuppression

Lymphocyte HVEM/BTLA co-expression after critical illness demonstrates severity indiscriminate upregulation, impacting critical illness-induced immunosuppression

IntroductionThe co-regulatory molecule, HVEM, can stimulate or inhibit immune function, but when co-expressed with BTLA, forms an inert complex preventing signaling. Altered HVEM or BTLA expression, separately have been associated with increased nosocomial infections in critical illness. Given that...

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Bibliographic Details
Main Authors: Michelle E. Wakeley, Brandon E. Armstead, Chyna C. Gray, Elizabeth W. Tindal, Daithi S. Heffernan, Chun-Shiang Chung, Alfred Ayala
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Medicine
Subjects:
HVEM
BTLA
trauma
sepsis
immune dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1176602/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1176602/full

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