Anticancer Asparaginases: Perspectives in Using Filamentous Fungi as Cell Factories

Anticancer Asparaginases: Perspectives in Using Filamentous Fungi as Cell Factories

The enzyme L-asparaginase (L-asparagine amidohydrolase) catalyzes the breakdown of L-asparagine into aspartate and ammonia, which leads to an anti-neoplastic activity stemming from its capacity to deplete L-asparagine concentrations in the bloodstream, and it is therefore used in cases of acute lymp...

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Bibliographic Details
Main Authors: Pedro Henrique Dias Garcia, Tales Alexandre Costa-Silva, Martí Morera Gómez, Fabiano Jares Contesini, Paula Renata Bueno Campos Canella, Patrícia de Oliveira Carvalho
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Catalysts
Subjects:
cell factory
L-asparaginase
filamentous fungi
anti-neoplastic
biopharmaceutical
Online Access:https://www.mdpi.com/2073-4344/13/1/200

Internet

https://www.mdpi.com/2073-4344/13/1/200

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