Selenite-induced ROS/AMPK/FoxO3a/GABARAPL-1 signaling pathway modulates autophagy that antagonize apoptosis in colorectal cancer cells

Selenite-induced ROS/AMPK/FoxO3a/GABARAPL-1 signaling pathway modulates autophagy that antagonize apoptosis in colorectal cancer cells

Abstract Previous studies have shown that selenium possessed chemotherapeutic effect against multiple malignant cancers, inducing diverse stress responses including apoptosis and autophagy. Selenite was previously shown to induce apoptosis and autophagy in colorectal cancer cells. However, the relat...

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Bibliographic Details
Main Authors: Hailing Yu, Yin Huang, Yanming Ge, Xiaopeng Hong, Xi Lin, Kexin Tang, Qiang Wang, Yang Yang, Weiming Sun, Yongquan Huang, Hui Luo
Format: Article
Language:English
Published: Springer 2021-09-01
Series:Discover Oncology
Subjects:
AMPK
Apoptosis
Autophagy
FoxO3a
Selenite
Online Access:https://doi.org/10.1007/s12672-021-00427-4

Internet

https://doi.org/10.1007/s12672-021-00427-4

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