Human laminin-111 and laminin-211 protein therapy prevents muscle disease progression in an immunodeficient mouse model of LAMA2-CMD

Human laminin-111 and laminin-211 protein therapy prevents muscle disease progression in an immunodeficient mouse model of LAMA2-CMD

Abstract Background Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating genetic disease caused by mutations in the LAMA2 gene. These mutations result in progressive muscle wasting and inflammation leading to delayed milestones, and reduced lifespan in affected patients. The...

Full description

Bibliographic Details
Main Authors: Pamela Barraza-Flores, Hailey J. Hermann, Christina R. Bates, Tyler G. Allen, Timothy T. Grunert, Dean J. Burkin
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Skeletal Muscle
Subjects:
LAMA2-CMD
MDC1A
Laminin-111
Immune system
Online Access:http://link.springer.com/article/10.1186/s13395-020-00235-4

Internet

http://link.springer.com/article/10.1186/s13395-020-00235-4

Similar Items