Triggering of NOD2 Receptor Converts Inflammatory Ly6Chigh into Ly6Clow Monocytes with Patrolling Properties

Triggering of NOD2 Receptor Converts Inflammatory Ly6Chigh into Ly6Clow Monocytes with Patrolling Properties

The signals that regulate the fate of circulating monocytes remain unknown. In the present study, we demonstrate that triggering of the NOD2 receptor by muramyl dipeptide (MDP) converts inflammatory Ly6Chigh monocytes into patrolling Ly6Clow monocytes. Administration of MDP to Nr4a1−/− mice, which l...

Full description

Bibliographic Details
Main Authors: Anne-Julie Lessard, Manon LeBel, Benoit Egarnes, Paul Préfontaine, Peter Thériault, Arnaud Droit, Alexandre Brunet, Serge Rivest, Jean Gosselin
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
inflammatory monocytes
patrolling monocytes
NOD2 receptor
monocyte polarization
inflammation
NOD2 agonists
innate response
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717310975

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717310975

Similar Items